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KMID : 0359720110290040347
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Journal of the Korean Neurological Association
2011 Volume.29 No. 4 p.347 ~ p.351
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Serial Follow-up of White Matter Connectivity in a Patient with Progressive Multifocal Leukoencephalopathy Presenting Clinical Improvement
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Chung Dan-Il
Oh Seong-Il
Oh Kyung-Pil
Paek Won-Ki
Kim Hee-Jin
Kim Seung-Hyun
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Abstract
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Progressive multifocal leukoencephalopathy (PML) is a fatal disease that is characterized by progressive demyelination of the cerebral white matter due to JC viral infection. We report serial magnetic resonance spectroscopy (MRS) and tractography changes in a patient with PML. After a three-cycle treatment with cidofovir and cytarabine, the patient exhibited remarkable improvements in motor and cognitive functions. Follow-up MRS and tractography revealed regeneration of the white-matter fibers. This is the first consecutive neuroimaging study showing improvements in neurological symptoms using MRS and tractography. Key Words: Progressive multifocal leukoencephalopathy, Magnetic resonance spectroscopy, Tractography
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KEYWORD
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Progressive multifocal leukoencephalopathy, Magnetic resonance spectroscopy, Tractography
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